ea0045p52 | Miscellaneous/other | BSPED2016
Hardwick Elise
, Han Bing
, Salomon-Estebanez Maria
, Padidela Raja
, Skae Mars
, Craigie Ross
, Cosgrove Karen
, Banerjee Indi
, Dunne Mark
Background: Congenital Hyperinsulinism in Infancy (CHI) is characterised by inappropriate insulin release from islet β-cells. We currently attribute hypoglycaemia to β-cell dysfunction because of defects in the ion channel genes ABCC8 or KCNJ11. However, the CHI pancreas is also associated with the inappropriate expression of foetal-like transcription factors and enhanced cell proliferation. We hypothesised that islet cell differentiation and neogen...